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A Randomized Controlled Trial on the Effects of Probiotic A (Protexin Vitality) as Supplement in the Treatment of Pulmonary Tuberculosis in Children

Date: May 04, 2016


Author: Lilian R. Santos, MD, DPPS University of Perpetual Help DALTA Medical Center

OBJECTIVE: To determine the potential of Protexin Vitality Probiotics as adjunctive in the treatment of pulmonary tuberculosis in children.
SETTING: Adopted communities of Last Supper Parish Church, Manila Times Las Piñas City.
STUDY DESIGN: Prospective Cohort Study, Randomized Controlled Trial, single blinded,
METHODOLOGY: The study population consist of 83 Children ages 2 1/2 – 12 ½  years old weighing <30kg, diagnosed with pulmonary tuberculosis. All participants were randomly selected and were assigned to either Group A, taking anti-TB medication supplemented with Probiotics and Group B taking anti-TB medication only.
OUTCOME MEASURES: Comparison of nutritional parameters: weight gain, height increase, increase triceps skin fold thickness; and comparison of recurrence rate of respiratory symptoms.

STATISTICAL ANALYSIS: Measures of central tendency and test homogeneity of samples include
T test and Chi square test. Repeated test of analysis of variance (ANOVA) was used to compare the two groups across time.
RESULT: The observed average weight gain in Group A (with Protexin) were better by 10% compared to Group B (Control).  With triceps skin fold thickness, group A has a bigger triceps skin fold thickness by 22% (Group A) 3.03cm, (Group B) 2.47 cm. The recurrence of respiratory symptoms, were less in both groups, however noted to be much less in group A. (with Protexin Vitality), with a reduced recurrence rate of 38% with no symptoms of fever, compared to control (Group B).Those who received Probiotics (Protexin) had mean height of  119.85 cm, and those without 114.76 cm a difference of 5.09 cm growth in height (by the end of August 2008).
CONCLUSION: In the treatment of PTB supplemented with Probiotics Protexin Vitality, there was a decrease in the recurrence of respiratory symptoms; a better weight gain and an increase in size of triceps skin fold thickness and height increase. It is recommended that probiotics be used to supplement tuberculosis treatment. Key words: Pulmonary tuberculosis, Probiotics, nutritional status

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